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High density lipoprotein inhibits the activation of sterol regulatory element-binding protein-1 in cultured cells
- Source :
-
FEBS Letters . Mar2010, Vol. 584 Issue 6, p1217-1222. 6p. - Publication Year :
- 2010
-
Abstract
- Abstract: A link between cellular uptake of high density lipoprotein (HDL) and regulation of sterol regulatory element-binding protein-1 (SREBP-1) was investigated in vitro. HDL decreased nuclear SREBP-1 levels as well as SREBP-1 target gene expression in HepG2 and HEK293 cells. However, HDL did not repress an exogenously expressed, constitutively active form of SREBP-1. HDL increased cellular cholesterol levels, and cellular cholesterol depletion by methyl-β-cyclodextrin abolished the effects of HDL. These results suggest that HDL inhibits the activation of SREBP-1 through a cholesterol-dependent mechanism, which may play an important role in regulating lipid synthetic pathways mediated by SREBP-1. [Copyright &y& Elsevier]
Details
- Language :
- English
- ISSN :
- 00145793
- Volume :
- 584
- Issue :
- 6
- Database :
- Academic Search Index
- Journal :
- FEBS Letters
- Publication Type :
- Academic Journal
- Accession number :
- 48605222
- Full Text :
- https://doi.org/10.1016/j.febslet.2010.02.034