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Pretreatment characteristics and clinical outcome of acute promyelocytic leukaemia patients according to the PML-RARα isoforms: a study of the PETHEMA group.
- Source :
-
British Journal of Haematology . Jul2001, Vol. 114 Issue 1, p99-103. 5p. - Publication Year :
- 2001
-
Abstract
- Of 167 newly diagnosed acute promyelocytic leukaemia patients, 83 patients were long (L)-form (50%), eight variable (V)-form (5%) and 76 short (S)-form (45%). The V-form and S-form groups presented a significantly higher percentage of patients with white blood cell counts > 10 × 109/l (P < 0·05). The S-form cases displayed a significantly higher number of cases with M3v microgranular features (P = 0·005) and CD34 expression (P < 0·0001). There were no differences between the three isoforms in complete remission (CR) rate (overall CR 90%), but the 3-year disease-free survival was lower for V-form cases than it was for L- and S-form cases (62% vs. 94% and 89%, P = 0·056). We conclude that the V-form and S-form types are associated with some negative prognostic features at diagnosis. However, our data were only able to demonstrate an association with adverse prognosis in the V-form type and, moreover, as the number of cases was limited, needs to be confirmed in large, uniformly treated series. [ABSTRACT FROM AUTHOR]
- Subjects :
- *TRANSCRIPTION factors
*ACUTE myeloid leukemia
*GENETICS
Subjects
Details
- Language :
- English
- ISSN :
- 00071048
- Volume :
- 114
- Issue :
- 1
- Database :
- Academic Search Index
- Journal :
- British Journal of Haematology
- Publication Type :
- Academic Journal
- Accession number :
- 4862564
- Full Text :
- https://doi.org/10.1046/j.1365-2141.2001.02915.x