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Gold nanoparticles functionalized by gadolinium–DTPA conjugate of cysteine as a multimodal bioimaging agent
- Source :
-
Bioorganic & Medicinal Chemistry Letters . Apr2010, Vol. 20 Issue 7, p2287-2291. 5p. - Publication Year :
- 2010
-
Abstract
- Abstract: The synthesis and characterization of gold nanoparticles coated with Gd-chelate (Au@GdL), where L is a conjugate of DTPA and cysteine, is described. These particles are obtained by the replacement of citrate from the gold nanoparticle surfaces with gadolinium chelate (GdL). The average size of Au@GdL is 14nm with a loading of GdL reaching up to 2.9×103 per particles, and they demonstrate very high R1 relaxivity (∼105 mM−1 s−1) as well as X-ray attenuation. The R1 relaxivity per [Gd] is 17.9mM−1 s−1. The present system also exhibits macrophage-specific property, as demonstrated by histological and TEM images as well as CT and MR, rendering itself as a new class of T1 multimodal CT/MR contrast agent. [Copyright &y& Elsevier]
Details
- Language :
- English
- ISSN :
- 0960894X
- Volume :
- 20
- Issue :
- 7
- Database :
- Academic Search Index
- Journal :
- Bioorganic & Medicinal Chemistry Letters
- Publication Type :
- Academic Journal
- Accession number :
- 48724795
- Full Text :
- https://doi.org/10.1016/j.bmcl.2010.02.002