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Polymorphisms in the 5′ upstream region of the FSH receptor gene, and their association with superovulation traits in Chinese Holstein cows
- Source :
-
Animal Reproduction Science . Jun2010, Vol. 119 Issue 3/4, p172-177. 6p. - Publication Year :
- 2010
-
Abstract
- Abstract: To identify a predictor to forecast superovulation response on the basis of associations between superovulation performance and gene polymorphism, variation in the bovine follicle stimulating hormone receptor (FSHR) gene was investigated using PCR-single-strand conformational (PCR-SSCP) and DNA sequencing. One single nucleotide polymorphism (SNP) of G-278A located in the 5′ upstream region of bovine FSHR gene was found in 118 Chinese Holstein cows treated for superovulation. Two SNPs of G-278A (GU253337) and A-320T (rs43676359) were analyzed. In polymorphic locus −278, all cows without superovulation response were mutations with genotypes of CD and DD. Cows with CC genotype had a significant increase in the total number of ova (TNO) (P <0.01), and produced more transferable embryos (NTE) than those of the CD and DD genotypes (P <0.01). At this locus, the additive effects seemed to be highly significant (P <0.01) and allele C was associated with an increase in the TNO and NTE. These results indicated that the FSHR is a potential marker for superovulation response and can be used as a predictor for superovulation in Chinese Holstein cows. [Copyright &y& Elsevier]
Details
- Language :
- English
- ISSN :
- 03784320
- Volume :
- 119
- Issue :
- 3/4
- Database :
- Academic Search Index
- Journal :
- Animal Reproduction Science
- Publication Type :
- Academic Journal
- Accession number :
- 48892375
- Full Text :
- https://doi.org/10.1016/j.anireprosci.2010.02.004