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Calmodulin—an often-ignored signal in osteoclasts.
- Source :
-
Annals of the New York Academy of Sciences . Apr2010, Vol. 1192 Issue 1, p358-364. 7p. 3 Graphs. - Publication Year :
- 2010
-
Abstract
- Calcium signaling plays a key role in bone turnover, regulating both osteoblasts and osteoclasts. Despite this the role of calmodulin, the primary intracellular calcium receptor regulatory protein, has received little attention. In this brief review, the function of Ca2+/calmodulin signaling in osteoclast development, function, and apoptosis is reviewed. Considerable evidence supports an important regulatory role for Ca2+/calmodulin signaling in each of these processes. The overall role of Ca2+/calmodulin in regulating bone turnover is also supported by animal and human studies showing that calmodulin antagonists preserve bone mass. [ABSTRACT FROM AUTHOR]
- Subjects :
- *CALMODULIN
*CALCIUM-binding proteins
*OSTEOCLASTS
*BONE cells
*PROTEINS
Subjects
Details
- Language :
- English
- ISSN :
- 00778923
- Volume :
- 1192
- Issue :
- 1
- Database :
- Academic Search Index
- Journal :
- Annals of the New York Academy of Sciences
- Publication Type :
- Academic Journal
- Accession number :
- 48961770
- Full Text :
- https://doi.org/10.1111/j.1749-6632.2009.05242.x