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Synthesis and in vitro studies of Gd–DTPA derivatives as new potential MRI contrast agents
- Source :
-
Tetrahedron Letters: International Organ for the Rapid Publication of Preliminary Communications in Organic Chemistry . May2010, Vol. 51 Issue 18, p2431-2433. 3p. - Publication Year :
- 2010
-
Abstract
- Abstract: A new type of dendritic molecules, Gd–DTPA derivatives, which work as a functionalized ligand coordinating gadolinium(III) ion at the center of their frameworks with different terminal moieties on the molecular surfaces, was readily synthesized with high yield. The structures were established by 1H, 13C NMR, and mass spectral studies. In vitro studies showed them to have enhanced r 1 value in albumin medium and good potentiality as MRI contrast agent. [Copyright &y& Elsevier]
Details
- Language :
- English
- ISSN :
- 00404039
- Volume :
- 51
- Issue :
- 18
- Database :
- Academic Search Index
- Journal :
- Tetrahedron Letters: International Organ for the Rapid Publication of Preliminary Communications in Organic Chemistry
- Publication Type :
- Academic Journal
- Accession number :
- 49108312
- Full Text :
- https://doi.org/10.1016/j.tetlet.2010.02.138