Back to Search
Start Over
Additive hypothermic effects of the 5-HT1A receptor agonist 8-OH-DPAT and the dopamine D2/3 receptor agonist 7-OH-DPAT in the rat.
- Source :
-
Acta Physiologica Scandinavica . Jul2001, Vol. 172 Issue 3, p205-209. 5p. 3 Graphs. - Publication Year :
- 2001
-
Abstract
- The objective of this study was to examine possible interactions between serotonergic and dopaminergic agents lowering core temperature via stimulation of 5-HT1A and dopamine (DA) D2 receptors, respectively. The effects of the 5-HT1A receptor agonist (±)-8-hydroxy-2-(di-n-propylamino)tetralin HBr (8-OH-DPAT) and the DA D2/3 receptor agonist 7-OH-DPAT on core temperature was monitored in adult male Wistar rats, approximately 300 g body weight. The temperature probe was connected to a PC-assisted temperature instrument, and an automated printer device was activated when the temperature reading had stabilized (±0.1 °C) for 10 s. As expected, 7-OH-DPAT [0.5 and 2.0 μmol kg–1 subcutaneous (s.c.)] as well as 8-OH-DPAT (0.15–2.4 μmol kg–1 s.c.), produced a dose-dependent hypothermia. When combined, there were additive effects of the two compounds, although the effects of 7-OH-DPAT were attenuated by 8-OH-DPAT at the higher doses (0.6–2.4 μmol kg–1), in all probability because of emerging DA D2 receptor blocking properties of the latter compound. [ABSTRACT FROM AUTHOR]
- Subjects :
- *SEROTONIN
*DOPAMINE receptors
*NEUROTRANSMITTER receptors
Subjects
Details
- Language :
- English
- ISSN :
- 00016772
- Volume :
- 172
- Issue :
- 3
- Database :
- Academic Search Index
- Journal :
- Acta Physiologica Scandinavica
- Publication Type :
- Academic Journal
- Accession number :
- 4951401
- Full Text :
- https://doi.org/10.1046/j.1365-201X.2001.00858.x