Methionine-Oxidized Amyloid Fibrils Are Poor Substrates for Human Methionine Sulfoxide Reductases A and B2.

The article discusses the basis between the association of methionine oxidation and amyloid diseases. It states that the oxidized amyloid fibrils and monomer reduction were compared to explore the link between amyloid diseases and methionine oxidation. Meanwhile, it considers methionine sulfoxide reductases (Msr) responsible for the oxidized methiones reduction. It also linked human degenerative and aging diseases such as Alzheimer's diseases with the decline of Msr.