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ILK mediates LPS-induced vascular adhesion receptor expression and subsequent leucocyte trans-endothelial migration†.
- Source :
-
Cardiovascular Research . May2010, Vol. 86 Issue 2, p283-292. 10p. 1 Diagram, 1 Chart, 5 Graphs. - Publication Year :
- 2010
-
Abstract
- Aims: The inflammatory response to injurious agents is tightly regulated to avoid adverse consequences of inappropriate leucocyte accumulation or failed resolution. Lipopolysaccharide (LPS)-activated endothelium recruits leucocytes to the inflamed tissue through controlled expression of membrane-associated adhesion molecules. LPS responses in macrophages are known to be regulated by integrin-linked kinase (ILK); in this study, we investigated the role of ILK in the regulation of the LPS-elicited inflammatory response in endothelium. [ABSTRACT FROM PUBLISHER]
- Subjects :
- *INTEGRINS
*ENDOTOXINS
*ENDOTHELIUM
*LEUCOCYTES
*CELL adhesion molecules
Subjects
Details
- Language :
- English
- ISSN :
- 00086363
- Volume :
- 86
- Issue :
- 2
- Database :
- Academic Search Index
- Journal :
- Cardiovascular Research
- Publication Type :
- Academic Journal
- Accession number :
- 49779054
- Full Text :
- https://doi.org/10.1093/cvr/cvq050