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Hypoxia-inducible factor-1-dependent mechanisms of vascularization and vascular remodelling.
- Source :
-
Cardiovascular Research . May2010, Vol. 86 Issue 2, p236-242. 7p. - Publication Year :
- 2010
-
Abstract
- The vascular system delivers oxygen and nutrients to every cell in the vertebrate organism. Hypoxia-inducible factor 1 (HIF-1) is a master regulator of hypoxic/ischaemic vascular responses, driving transcriptional activation of hundreds of genes involved in vascular reactivity, angiogenesis, arteriogenesis, and the mobilization and homing of bone marrow-derived angiogenic cells. This review will focus on the pivotal role of HIF-1 in vascular homeostasis, the involvement of HIF-1 in vascular diseases, and recent advances in targeting HIF-1 for therapy in preclinical models. [ABSTRACT FROM PUBLISHER]
Details
- Language :
- English
- ISSN :
- 00086363
- Volume :
- 86
- Issue :
- 2
- Database :
- Academic Search Index
- Journal :
- Cardiovascular Research
- Publication Type :
- Academic Journal
- Accession number :
- 49779057
- Full Text :
- https://doi.org/10.1093/cvr/cvq045