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RhoGDI signaling provides targets for cancer therapy
- Source :
-
European Journal of Cancer . May2010, Vol. 46 Issue 7, p1252-1259. 8p. - Publication Year :
- 2010
-
Abstract
- Rho GDP-Dissociation Inhibitors (RhoGDIs) are important regulators of the Rho family of small GTPases. The expression of RhoGDIs is altered in a variety of cancers and they have been shown to mediate several processes during tumorigenesis and cancer progression. Using examples of RhoGDI-mediated signaling and expression patterns in endothelial cells as well as pancreatic, breast, and bladder cancer, the multitude of potential cancer therapeutic targets presented by a better understanding of their function is illustrated. Several novel therapeutic strategies are proposed for intervening in RhoGDI signaling, and potential complications arising from their implementation are discussed. [Copyright &y& Elsevier]
Details
- Language :
- English
- ISSN :
- 09598049
- Volume :
- 46
- Issue :
- 7
- Database :
- Academic Search Index
- Journal :
- European Journal of Cancer
- Publication Type :
- Academic Journal
- Accession number :
- 49817239
- Full Text :
- https://doi.org/10.1016/j.ejca.2010.02.025