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Gastric hyposecretion in esophageal squamous-cell carcinomas.
- Source :
-
Digestive Diseases & Sciences . May2010, Vol. 55 Issue 5, p1349-1355. 7p. 3 Charts. - Publication Year :
- 2010
-
Abstract
- Recently, gastric fundic atrophy is reported to be an independent risk factor for esophageal squamous-cell carcinoma (ESCC). The aim of this study is to investigate the acid secretory level in ESCC in a case-control study. From April 2004 to March 2008, 100 consecutive subjects with early ESCC and 100 age- and sex-matched asymptomatic controls were prospectively enrolled. Gastrin-stimulated acid output was assessed by endoscopic gastrin test. Conditional regression analyses were used to adjust for other potential confounders. Multivariate analyses revealed a strong association between profound hypochlorhydria and ESCC with odds ratio (95% confidence interval): 6.0 (1.9-18.4). The association remained significant after adjusting for the effect of gastric atrophy as a covariate. The association became stronger as the ESCC developed more distal site of the esophagus. This study indicates that profound hypochlorhydria is a strong independent risk factor for ESCC even after adjusting for the influence of gastric atrophy. [ABSTRACT FROM AUTHOR]
- Subjects :
- *SQUAMOUS cell carcinoma
*STOMACH cancer
*GASTRIC acid
*ATROPHY
*PYLORIC spasms
*BIOPSY
*ENZYMES
*ESOPHAGEAL tumors
*HELICOBACTER diseases
*HELICOBACTER pylori
*LONGITUDINAL method
*REGRESSION analysis
*LOGISTIC regression analysis
*CASE-control method
*ENDOSCOPIC gastrointestinal surgery
*ATROPHIC gastritis
*DISEASE complications
Subjects
Details
- Language :
- English
- ISSN :
- 01632116
- Volume :
- 55
- Issue :
- 5
- Database :
- Academic Search Index
- Journal :
- Digestive Diseases & Sciences
- Publication Type :
- Academic Journal
- Accession number :
- 50244514
- Full Text :
- https://doi.org/10.1007/s10620-009-0853-x