Non-Pungent Capsaicin Analogs (Capsinoids) Increase Metabolic Rate and Enhance Thermogenesis via Gastrointestinal TRPV1 in Mice.

The article presents which investigates the effect of capsinoids on the metabolic rate and thermogenesis in mice through gastrointestinal transient receptor potential vanilloid 1 (TRPV1). The study conducted an respiratory gas analysis of male adult C57BL/6 strain wild-type (WT) mice and TRPV1 knockout (KO) mice to measure the energy expenditure and fat oxidation using TRPV1. The results show that capsinoids increase the energy expenditure and enhance thermogenesis through TRPV1.