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Immunodominance analysis through interactions of CD8+ T cells and DCs in lymph nodes
- Source :
-
Mathematical Biosciences . May2010, Vol. 225 Issue 1, p53-58. 6p. - Publication Year :
- 2010
-
Abstract
- Abstract: Immunodominance is a common phenomenon observed in multiple epitopes immune systems. Previous studies hypothesize that the competition among CD8+ T cell responses against different epitopes can be used to explain immunodominance. This paper proposes a mathematical model that describes the dynamics of CD8+ T cells primed by antigen-presenting dendritic cells (DCs) in the lymph nodes, and shows that the overall avidity of the interactions between peptide-specific T cells and cognate antigen-bearing DCs may determine the immunodominance. The model suggests the probability that a peptide-specific T cell be immunodominant is proportional to (1) the cognate T cell receptor (TCR) affinity, (2) the number of complexes of cognate peptide and major histocompatibility complex (pMHC) per DC, and (3) the half-life of cognate peptide-specific pMHC. The model predicts a threshold density of pMHC complexes for T cell activation. These observations from the mathematical model are consistent with experimental studies in the open literature. For DC-based vaccine design, the model suggests a strategy of immunotherapy based on the injection of cognate antigen-pulsed DCs. [Copyright &y& Elsevier]
Details
- Language :
- English
- ISSN :
- 00255564
- Volume :
- 225
- Issue :
- 1
- Database :
- Academic Search Index
- Journal :
- Mathematical Biosciences
- Publication Type :
- Periodical
- Accession number :
- 50260844
- Full Text :
- https://doi.org/10.1016/j.mbs.2010.01.009