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Detection of chronic lymphocytic leukemia cell surface markers using surface enhanced Raman scattering gold nanoparticles
- Source :
-
Cancer Letters . Jun2010, Vol. 292 Issue 1, p91-97. 7p. - Publication Year :
- 2010
-
Abstract
- Abstract: Selective targeting and detection of a hematologic malignancy, chronic lymphocytic leukemia, using surface enhanced Raman scattering (SERS) gold nanoparticles is reported. The functional nanoparticles were composed of a gold core onto which an optical reporter dye was adsorbed, protected from aggregation by grafted polyethyleneglycol, and targeted to CD19 antigen by antibodies. The signals were detected by dark-field microscopy and Raman spectrometry. The observation that the Raman signals are not disrupted by several traditional pathology stains indicates advantages over fluorescence methods. [Copyright &y& Elsevier]
Details
- Language :
- English
- ISSN :
- 03043835
- Volume :
- 292
- Issue :
- 1
- Database :
- Academic Search Index
- Journal :
- Cancer Letters
- Publication Type :
- Academic Journal
- Accession number :
- 50268581
- Full Text :
- https://doi.org/10.1016/j.canlet.2009.11.011