Ancestral Origins and Worldwide Distribution of the PRNP 200K Mutation Causing Familial Creutzfeldt-Jakob Disease.

Studies the ancestral origins and worldwide distribution of the PRNP 200K mutation causing familial Creutzfeldt-Jakob disease (CDJ). Selection of microsatellite markers on the PRNP gene on chromosome 20p12-pter and an intragenic single-nucleotide polymorphism at the PRNP codon 129; Role of founder effect and independent mutational events for the geographic distribution of heridatary CJD associated with the 200K mutation.