Tandem Michael addition/intramolecular isocyanide [3 + 2] cycloaddition: highly diastereoselective one pot synthesis of fused oxazolinesElectronic supplementary information (ESI) available: Detailed experimental procedures and analytical data. CCDC 753607(2a) and CCDC 761982(6b). For ESI and crystallographic data in CIF or other electronic format see DOI: 10.1039/c001617a

A base-catalyzed tandem Michael addition/intramolecular isocyanide [3 + 2] cycloaddition of ethyl isocyanoacetate and Michael acceptors with tethered carbonyl groups is described. This reaction leads to the formation of fused oxazolines in a highly diastereoselective manner under very mild conditions. [ABSTRACT FROM AUTHOR]