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Sequential Changes in Mucosal Immunity after Hemorrhagic Shock.
- Source :
-
American Surgeon . Aug2001, Vol. 67 Issue 8, p797. 5p. 3 Graphs. - Publication Year :
- 2001
-
Abstract
- Immunoinflammatory responses after shock and major trauma are characterized by an early hyperinflammatory response and later by compensatory anti-inflammatory host mediator production. This late phase is associated with depressed immune function that has been causally linked with post-traumatic infectious complications and late organ failure. Gut barrier failure is noted in this setting and may be an important source of nosocomial infections and organ failure. Secretory immunoglobulin A (sIgA) is the predominant immunoglobin at mucosal surfaces and is difficult to quantify in luminal secretions. Attempts to normalize sIgA concentrations may not be accurate and/or may not be applicable in vivo. A method using mucosal immunization with cholera toxin (ChT) to normalize gut sIgA levels was used to assess serial changes in sIgA after hemorrhagic shock (HS) in rodents. Total and anti-ChT sIgA levels were highly variable in both HS and sham animals. However, when normalized using the specific anti-ChT/total sIgA ratio, differences were clearly evident. This ratio was depressed between 3 and 10 days post-HS. The specific anti-ChT/total sIgA ratio is a reliable index of secretory antibody at gut luminal surfaces. Impaired mucosal immune function occurred in a time frame consistent with development of late nosocomial infections. This may be important mechanistically in the development of these infectious complications. [ABSTRACT FROM AUTHOR]
- Subjects :
- *IMMUNOGLOBULIN A
*HEMORRHAGIC shock
Subjects
Details
- Language :
- English
- ISSN :
- 00031348
- Volume :
- 67
- Issue :
- 8
- Database :
- Academic Search Index
- Journal :
- American Surgeon
- Publication Type :
- Academic Journal
- Accession number :
- 5059608
- Full Text :
- https://doi.org/10.1177/000313480106700818