Ar išsėtinė sklerozė gali būti paveldima? Klinikiniai atvejai.

The etiology of multiple sclerosis is unknown. It is likely to be multifactorial disease and the genetic factors play a role in it's pathophysiology. Human leucocyte antigen system is known to contribute to disease susceptibility. Its alleles are responsible for the dis ease development and relapses frequency and they are different according to geografic location. As the mode of inheritance is un known, multiple scle rosis was attributed to the multiplex group of non-mendelian diseases. It is determined by the series of genes situated in the different genetic regions, their effects are summarizing and acting with different environ mental factors. Among relatives of multiple sclerosis patients, the risk of be ing affected is influenced by the degree of identity of the ge nome. The age-adjusted life time risk is higher for first-de gree than for sec ond-de gree rel a tives. There is concordance for age at on set for affected parent-child group and siblings and the clinical course of multiple sclerosis is similar between siblings. In this article we discuss two clinical cases of familial multiple sclerosis: in the first case diagnosis of multiple sclerosis was determined for siblings, in the second diagnosis of multiple sclerosis was stated for mother and for her son diagnosis of acute disseminated encephalomyelitis was as certained. [ABSTRACT FROM AUTHOR]