A new safety-catch protecting group and linker for solid-phase synthesis

Authors :: Thennarasu, Sathiah
Liu, Chuan-Fa
Source :: Tetrahedron Letters: International Organ for the Rapid Publication of Preliminary Communications in Organic Chemistry. Jun2010, Vol. 51 Issue 24, p3218-3220. 3p.
Publication Year :: 2010
Abstract: Abstract: The use of two derivatives of 2-methoxy-4-methylsulfinylbenzyl alcohol is demonstrated as a safety-catch protecting group and linker for solid-phase peptide synthesis. The protecting group and linker are stable to TFA and are readily removed under reductive acidolytic conditions. [Copyright &y& Elsevier]

Subjects :: *SOLID-phase synthesis
*ALCOHOL
*CHEMICAL reduction
*PEPTIDE synthesis
*ACETIC acid
*CHEMICAL reactions

Language :: English
ISSN :: 00404039
Volume :: 51
Issue :: 24
Database :: Academic Search Index
Journal :: Tetrahedron Letters: International Organ for the Rapid Publication of Preliminary Communications in Organic Chemistry
Publication Type :: Academic Journal
Accession number :: 50694801
Full Text :: https://doi.org/10.1016/j.tetlet.2010.04.047