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Therapeutic effect of Linum usitatissimum (flaxseed/linseed) fixed oil on acute and chronic arthritic models in albino rats.
- Source :
-
Inflammopharmacology . Jun2010, Vol. 18 Issue 3, p127-136. 10p. 2 Diagrams, 5 Charts. - Publication Year :
- 2010
-
Abstract
- The present study was undertaken to assess the activity/anti-inflammatory potential of Linum usitatissimum fixed oil against castor oil-induced diarrhoea, turpentine oil-induced joint oedema, formaldehyde and Complete Freund’s Adjuvant (CFA)-induced arthritis in Wistar albino rats. The oil intraperitoneally, significantly inhibited the castor oil-induced diarrhoea and turpentine oil-induced exudative joint oedema in a dose-dependent manner. Significant inhibitory effect of L. usitatissimum fixed oil was observed in formaldehyde-induced proliferative global oedematous arthritis when given intraperitoneally, with significant checking of the serum glutamic oxaloacetic acid transaminase and serum glutamic pyruvic acid transaminase. Further, L. usitatissimum fixed oil showed a significant dose-dependent protective effect against CFA-induced arthritis as well. Secondary lesions produced by CFA due to a delayed hypersensitivity reaction were also reduced in a significant manner. Anti-inflammatory activity of L. usitatissimum fixed oil can be attributed to the presence of alpha linolenic acid (57.38%, an omega-3 fatty acid, 18:3, n-3) having dual inhibitory effect on arachidonate metabolism resulting in suppressed production of proinflammatory n-6 eicosanoids (PGE2, LTB4) and diminished vascular permeability. These observations suggest possible therapeutic potential of L. usitatissimum fixed oil in inflammatory disorders like rheumatoid arthritis. [ABSTRACT FROM AUTHOR]
- Subjects :
- *FLAX
*THERAPEUTIC use of flaxseed
*LINSEED oil
*RATS
*ARTHRITIS
*THERAPEUTICS
Subjects
Details
- Language :
- English
- ISSN :
- 09254692
- Volume :
- 18
- Issue :
- 3
- Database :
- Academic Search Index
- Journal :
- Inflammopharmacology
- Publication Type :
- Academic Journal
- Accession number :
- 50723958
- Full Text :
- https://doi.org/10.1007/s10787-010-0033-9