Minor Lesion Mutational Spectrum of the Entire NF1 Gene Does Not Explain Its High Mutability but Points to a Functional Domain Upstream of the GAP-Related Domain.

Examines the mutational spectrum of the entire neurofibromatosis type 1 gene. Aberrations in the coding sequence and splice sites; Distribution of whole gene from exon 1 to exon 47; Identification of clustered missense in two genetic regions.