Back to Search
Start Over
Role of vasostatin-1 C-terminal region in fibroblast cell adhesion.
- Source :
-
Cellular & Molecular Life Sciences . Jun2010, Vol. 67 Issue 12, p2107-2118. 12p. 7 Graphs. - Publication Year :
- 2010
-
Abstract
- Fibroblast adhesion can be modulated by proteins released by neuroendocrine cells and neurons, such as chromogranin A (CgA) and its N-terminal fragment vasostatin-1 (VS-1, CgA1–78). We have investigated the mechanisms of the interaction of VS-1 with fibroblasts and of its pro-adhesive activity and have found that the proadhesive activity of VS-1 relies on its interaction with the fibroblast membrane via a phospholipid-binding amphipathic α-helix located within residues 47–66, as well as on the interaction of the adjacent C-terminal region 67–78, which is structurally similar to ezrin–radixin–moesin-binding phosphoprotein 50 (a membrane-cytoskeleton adapter protein), with other cellular components critical for the regulation of cell cytoskeleton. [ABSTRACT FROM AUTHOR]
- Subjects :
- *CHROMOGRANINS
*STATINS (Cardiovascular agents)
*CELL adhesion
*NEURONS
*FIBROBLASTS
Subjects
Details
- Language :
- English
- ISSN :
- 1420682X
- Volume :
- 67
- Issue :
- 12
- Database :
- Academic Search Index
- Journal :
- Cellular & Molecular Life Sciences
- Publication Type :
- Academic Journal
- Accession number :
- 50905507
- Full Text :
- https://doi.org/10.1007/s00018-010-0319-5