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Negative Association of c-fos Expression as a Favorable Prognostic Indicator in Gastric Cancer
- Source :
-
Archives of Medical Research . Apr2010, Vol. 41 Issue 3, p201-206. 6p. - Publication Year :
- 2010
-
Abstract
- Background and Aims: The onco-protein c-fos was previously linked to favorable prognosis of gastric cancer (GC) without further validations. The present study was designed to address the issue based on a cohort of Chinese patients. Methods: Expression of c-fos was determined by immunohistochemical staining in specimens from 58 patients with GC who underwent surgical resection. The relationships between c-fos expression and clinicopathological and prognostic variables were further evaluated. Results: Expression of c-fos in tumor epithelia was observed in 39 (67.2%) patients. The protein was also positively expressed in lymphocytes within tumors and para-tumor epithelia. Tumors with positive expression of c-fos in tumor epithelia had a smaller size and marginally earlier T stage in all patients and/or those who underwent curative resection. Univariate analysis showed that patients with positive c-fos expression in tumor epithelia had significantly prolonged overall and tumor-free survival. Cox regression analysis revealed that c-fos expression in tumor epithelia was an independent or potential independent indicator of improved prognosis in different subgroups of patients. Expression of c-fos in para-tumor epithelia and intra-tumor lymphocytes was not associated with clinicopathological variables and long-term outcomes in patients. Conclusions: Our data demonstrated that c-fos expression was negatively associated with tumor progression and was predictive for favorable survival in patients with GC. [Copyright &y& Elsevier]
Details
- Language :
- English
- ISSN :
- 01884409
- Volume :
- 41
- Issue :
- 3
- Database :
- Academic Search Index
- Journal :
- Archives of Medical Research
- Publication Type :
- Academic Journal
- Accession number :
- 51291835
- Full Text :
- https://doi.org/10.1016/j.arcmed.2010.04.009