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Antibody Response in Individuals Infected with Avian Influenza A (H5N1) Viruses and Detection of Anti-H5 Antibody among Household and Social Contacts.
- Source :
-
Journal of Infectious Diseases . 12/1/99, Vol. 180 Issue 6, p1763. 8p. 3 Charts, 2 Graphs. - Publication Year :
- 1999
-
Abstract
- The first documented outbreak of human respiratory disease caused by avian influenza A (H5N1) viruses occurred in Hong Kong in 1997. The kinetics of the antibody response to the avian virus in H5N1-infected persons was similar to that of a primary response to human influenza A viruses; serum neutralizing antibody was detected, in general, ...14 days after symptom onset. Cohort studies were conducted to assess the risk of human-to-human transmission of the virus. By use of a combination of serologic assays, 6 of 51 household contacts, 1 of 26 tour group members, and none of 47 co-workers exposed to H5N1-infected persons were positive for H5 antibody. One H5 antibody-positive household contact, with no history of poultry exposure, provided evidence that human-to-human transmission of the avian virus may have occurred through close physical contact with H5N1-infected patients. In contrast, social exposure to case patients was not associated with H5N1 infection. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 00221899
- Volume :
- 180
- Issue :
- 6
- Database :
- Academic Search Index
- Journal :
- Journal of Infectious Diseases
- Publication Type :
- Academic Journal
- Accession number :
- 5145077
- Full Text :
- https://doi.org/10.1086/315137