Cancer-associated IDH1 mutations produce 2-hydroxyglutarate.

Authors :: Dang, Lenny
White, David W.
Gross, Stefan
Bennett, Bryson D.
Bittinger, Mark A.
Driggers, Edward M.
Fantin, Valeria R.
Jang, Hyun Gyung
Jin, Shengfang
Keenan, Marie C.
Marks, Kevin M.
Prins, Robert M.
Ward, Patrick S.
Yen, Katharine E.
Liau, Linda M.
Rabinowitz, Joshua D.
Cantley, Lewis C.
Thompson, Craig B.
Vander Heiden, Matthew G.
Su, Shinsan M.
Source :: Nature. 6/17/2010, Vol. 465 Issue 7300, p966-966. 1p.
Publication Year :: 2010
Abstract: The article presents a supplement to the article "Cancer-associated IDH1 mutations produce 2-hydroxyglutarate" that was published in the 2010 issue, which discusses accumulation of R(—)-2-hydroxyglutarate (2HG) as a possible cause of oncogenesis.

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