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Condensins Promote Coorientation of Sister Chromatids During Meiosis I in Budding Yeast.
- Source :
-
Genetics . May2010, Vol. 185 Issue 1, p55-6SI. 16p. - Publication Year :
- 2010
-
Abstract
- The condensin complex is a key determinant of higher-ordered chromosome structure. We show here that the complex is also important for the correct alignment of chromosomes on the meiosis I spindle. Unlike during mitosis and meiosis II, when sister chromatids attach to microtubules emanating from opposite spindle poles (biorientation), accurate meiosis I chromosome segregation requires that sister chromatids attach to microtubules emanating from the same spindle pole (coorientation). The monopolin complex, consisting of Lrs4, Csm1, and the meiosis-specific component Mam1, brings about meiosis I coorientation. We find that in the absence of functional condensin complexes, a fraction of sister kinetochores biorient on the meiosis I spindle and association of the monopolin complex subunit Mam1 with kinetochores is decreased. Our studies uncover a new locus-specific effect of the condensin complex. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 00166731
- Volume :
- 185
- Issue :
- 1
- Database :
- Academic Search Index
- Journal :
- Genetics
- Publication Type :
- Academic Journal
- Accession number :
- 51534049
- Full Text :
- https://doi.org/10.1534/genetics.110.115139