CZYNNIKI RYZYKA ROZWOJU NEFROPATII CUKRZYCOWEJ U DZIECI.

Nephropathy is one of the major vascular complications present in adults with diabetes mellitus type 1 (DM1) and is the most common cause of chronic kidney disease in adults. Currently, in everyday medical practice, microalbminuria is used as a marker to identify individuals at risk of nephropathy, however it only occasionally may be observed during the first 5 years from the diagnosis of DM1. Despite of intensive research in the field of diabetic nephropathy development, its pathomechanism is still not fully understood. In the presented work we describe the correlation between N-acetyl-β-D-glucosaminidase, cistatin C and the development of microalbuminuria. Also, we attempted to explain therelations between the degree of metabolic compliance (HbA1c), the level of vascular endothelial growth factor (VEGF), tumor necrosis factor (TNF-β), interleukin 6, 12, 10 (IL-6, IL-12, IL-10) and the development of diabetic nephropathy in children. Among the analyzed immunologic markers, those prognostic for occurrence of microalbuminuria and for development of pathologic changes in kidneys in the course of DM1 in children were pointed out. Plausibly, identification of early markers of the developing diabetic nephropathy might contribute to better understanding of its pathogenesis and also to research of novel therapeutic options aimed at improvement of quality of life of DM1 patients by means of slowdown or even avoidance of the development of late vascular complications. [ABSTRACT FROM AUTHOR]