Síndrome nefrótico: Particularidades clínicas e histopatológicas en 58 niños.

Objective. To study the epidemiological, clinical and histopathological features of children with nephrotic syndrome (NS) and its response to the treatment. Material and methods. 58 patients treated in the hospital in five years were study. Results. 31 patients were male (53%), the gender ratio was 1: 1 and the age from 1 and 14 years. The higher frequency (38%) was observed in the group of 2-6 years. All showed edema, hypoalbuminemia, hyperlipidemia, hypercholesterolemia and massive proteinuria. 25 children (43%) had hematuria, and its permanence was related to resistance to the treatment. Initially, 19 patients (33%) had hypertension. Thirty six (63%) maintained normal values of urea and creatinine and in 28 of them (48%), the C3 fraction also was normal. Nine patients (16%), renal biopsy was made to them, being observed minimal injuries, such as more frequent histopathological finding. The majority (61%) hod good response to steroids. Conclusions. The NS is the disease with the higher morbidity among the renal diseases in children in our hospital and it is the fourth reason for consultation. In children it usually has good prognosis, but in some cases with resistant to steroids, it is necessary to assess renal function periodically and to do renal biopsy at the same time, following various therapeutic strategies. [ABSTRACT FROM AUTHOR]