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The number of circulating recent thymic emigrants is severely reduced 1 year after a single dose of alemtuzumab in renal transplant recipients.
- Source :
-
Transplant International . Aug2010, Vol. 23 Issue 8, p786-795. 10p. - Publication Year :
- 2010
-
Abstract
- To better understand the kinetics of the delayed reconstitution of peripheral CD4+ T-cells after depletion with a single administration of alemtuzumab (AL) for renal transplantation, we evaluated in these patients the percentage and absolute number of recent thymic emigrants (RTEs) CD4+ T cells, together with naive and memory subsets, defined by the analysis of CD31, CD45RA and CCR7 expression, and compared with patients treated with a nondepleting protocol based on basiliximab, and with healthy controls. In AL-treated patients, the number of circulating CD4+ T cells was greatly reduced 1 year after the infusion ( P < 0.01), but the proportions of central memory, effector memory and terminally differentiated effector memory subsets among CD4+ cells were significantly increased. On the contrary, the proportion and the absolute number of naïve CD4+ T cells, although progressively increasing with time, were severely reduced. In particular, the absolute number of RTEs had only very slight increase with time ( P = 0.049) and was dramatically low 1 year after the therapy ( P < 0.01 vs. healthy controls; P < 0.05 vs. basiliximab-treated transplant recipients). These data suggest that a prolonged defective thymic output after AL therapy in renal transplant recipients is one of the main causes of the persistent CD4+ T-cell lymphopenia observed in these patients. [ABSTRACT FROM AUTHOR]
- Subjects :
- *T cells
*KIDNEY transplantation
*LYMPHOCYTES
*GENE expression
*LYMPHOPENIA
Subjects
Details
- Language :
- English
- ISSN :
- 09340874
- Volume :
- 23
- Issue :
- 8
- Database :
- Academic Search Index
- Journal :
- Transplant International
- Publication Type :
- Academic Journal
- Accession number :
- 51878124
- Full Text :
- https://doi.org/10.1111/j.1432-2277.2010.01052.x