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Genetic and biological characterization of avian influenza H5N1 viruses isolated from wild birds and poultry in Western Siberia.
- Source :
-
Archives of Virology . Jul2010, Vol. 155 Issue 7, p1145-1150. 6p. 1 Diagram, 2 Charts. - Publication Year :
- 2010
-
Abstract
- Three viruses included in the study were isolated from dead birds (A/duck/Omsk/1822/2006, A/chicken/Reshoty/02/2006, and A/duck/Tuva/01/2006), whereas the virus A/common gull/Chany/P/2006 was isolated from an apparently healthy gull during outbreaks of highly pathogenic avian influenza in Russia in 2006. The intravenous pathogenicity index (IVPI) of viruses A/duck/Omsk/1822/2006, A/chicken/Reshoty/02/2006, and A/duck/Tuva/01/2006 ranged from 2.7 to 3.0, while the virus A/common gull/Chany/P/2006 had a markedly lower IVPI of 1.7. The virus A/common gull/Chany/P/2006 had a unique pattern of six amino acid substitutions in the regions of viral proteins crucial for virulence of H5N1 viruses. We hypothesize that these substitutions may affect the pathogenicity of A/common gull/Chany/P/2006. [ABSTRACT FROM AUTHOR]
- Subjects :
- *H5N1 Influenza
*AVIAN influenza
*VIRUS diseases
*BIRDS
*POULTRY
Subjects
Details
- Language :
- English
- ISSN :
- 03048608
- Volume :
- 155
- Issue :
- 7
- Database :
- Academic Search Index
- Journal :
- Archives of Virology
- Publication Type :
- Academic Journal
- Accession number :
- 51881035
- Full Text :
- https://doi.org/10.1007/s00705-010-0676-2