CHEMOPREVENTION OF BREAST CANCER.

Breast cancer represents one of the most important problems of clinical and experimental oncology. Excluding cancers of the skin, breast cancer is the most frequent neoplasm in women, forming approximately 30 % of all tumours. The knowledge on the possibility and suitability of the prevention of breast cancer rose sharply in last years. The strategy of chemoprevention seems to be promising for reducing cancer incidence both in well-defined high-risk individuals and also in the general population. Several clinical studies have shown that in high-risk women for breast cancer, the drugs such as non-steroidal inflammatory drugs, selective oestrogen receptor modulators and retinoids, may reduce this risk. Chemopreventive studies carried out on model laboratory animals have an important role in new drugs efficacy evaluation in pre-clinical tests. Our group tested several groups of chemopreventive substances in female rat mammary carcinogenesis. [ABSTRACT FROM AUTHOR]