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PCBP1 Suppresses the Translation of Metastasis-Associated PRL-3 Phosphatase
- Source :
-
Cancer Cell . Jul2010, Vol. 18 Issue 1, p52-62. 11p. - Publication Year :
- 2010
-
Abstract
- Summary: Overexpression of phosphatase of regenerating liver (PRL)-3 is associated with the progression of diverse human cancers. We show that the overexpression of PRL-3 protein is not directly associated with its transcript levels, indicating the existence of an underlying posttranscriptional regulation. The 5′ untranslanted region (UTR) of PRL-3 mRNA possesses triple GCCCAG motifs capable of suppressing mRNA translation through interaction with PolyC-RNA-binding protein 1 (PCBP1), which retards PRL-3 mRNA transcript incorporation into polyribosomes. Overexpression of PCBP1 inhibits PRL-3 expression and inactivates AKT, whereas knockdown of PCBP1 causes upregulation of PRL-3 protein levels, activation of AKT, and promotion of tumorigenesis. An inverse correlation between protein levels of PRL-3 and PCBP1 in human primary cancers supports the clinical relevance. [Copyright &y& Elsevier]
Details
- Language :
- English
- ISSN :
- 15356108
- Volume :
- 18
- Issue :
- 1
- Database :
- Academic Search Index
- Journal :
- Cancer Cell
- Publication Type :
- Academic Journal
- Accession number :
- 51921578
- Full Text :
- https://doi.org/10.1016/j.ccr.2010.04.028