Back to Search
Start Over
Behavioral evaluation of transgenic mice with CNS expression of IFN-α by elevated plus-maze and Porsolt swim test
- Source :
-
Neuroscience Letters . Aug2010, Vol. 479 Issue 3, p287-291. 5p. - Publication Year :
- 2010
-
Abstract
- Abstract: Chronic IFN-α treatment as an antiviral or anti-cancer therapy can lead to severe psychiatric complications, including depression and anxiety in patients. In many animal models of IFN-α-induced behavioral dysfunction, the opposite results have frequently been reported. In an attempt to overcome the limitation of pharmacological studies, IFN-α-transgenic mice with CNS-targeted expression of the IFN-α transgene were used to study depression and anxiety-like behaviors by Porsolt swim and elevated plus-maze assays, respectively. Interestingly, chronic stimulation of IFN-α signaling in mouse brains did not cause depression or anxiety as measured by these tests in comparison with wild-type littermates. This observation suggests that factors other than IFN-α may be necessary for the development of psychiatric complications following IFN-α therapy in patients. [Copyright &y& Elsevier]
Details
- Language :
- English
- ISSN :
- 03043940
- Volume :
- 479
- Issue :
- 3
- Database :
- Academic Search Index
- Journal :
- Neuroscience Letters
- Publication Type :
- Academic Journal
- Accession number :
- 51922514
- Full Text :
- https://doi.org/10.1016/j.neulet.2010.05.082