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Thermostable formulations of a hepatitis B vaccine and a meningitis A polysaccharide conjugate vaccine produced by a spray drying method

Thermostable formulations of a hepatitis B vaccine and a meningitis A polysaccharide conjugate vaccine produced by a spray drying method

Authors :
Chen, D.
Kapre, S.
Goel, A.
Suresh, K.
Beri, S.
Hickling, J.
Jensen, J.
Lal, M.
Preaud, J.M.
LaForce, M.
Kristensen, D.
Source :
Vaccine. Jul2010, Vol. 28 Issue 31, p5093-5099. 7p.
Publication Year :
2010

Abstract

Abstract: Thermostable vaccines promise to simplify the logistics of vaccine distribution and expand the immunization coverage. In this study, a pilot-scale spray drying process was developed and used to produce glassy state formulations of a recombinant hepatitis B (HepB) vaccine containing aluminum adjuvant and Neisseria meningitidis A (MenA) protein–polysaccharide conjugate vaccine, representing two common types of subunit vaccines in use today: the spray-dried HepB vaccine formulations were stable for at least 24 months at 37°C while several MenA vaccine formulations exhibited complete stability at temperatures up to 60°C. This study demonstrates the feasibility of producing thermostable vaccines with advanced processing and formulation technologies. [Copyright &y& Elsevier]

Details

Language :
English
ISSN :
0264410X
Volume :
28
Issue :
31
Database :
Academic Search Index
Journal :
Vaccine
Publication Type :
Academic Journal
Accession number :
52348705
Full Text :
https://doi.org/10.1016/j.vaccine.2010.04.112