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Thermostable formulations of a hepatitis B vaccine and a meningitis A polysaccharide conjugate vaccine produced by a spray drying method
Thermostable formulations of a hepatitis B vaccine and a meningitis A polysaccharide conjugate vaccine produced by a spray drying method
- Source :
-
Vaccine . Jul2010, Vol. 28 Issue 31, p5093-5099. 7p. - Publication Year :
- 2010
-
Abstract
- Abstract: Thermostable vaccines promise to simplify the logistics of vaccine distribution and expand the immunization coverage. In this study, a pilot-scale spray drying process was developed and used to produce glassy state formulations of a recombinant hepatitis B (HepB) vaccine containing aluminum adjuvant and Neisseria meningitidis A (MenA) protein–polysaccharide conjugate vaccine, representing two common types of subunit vaccines in use today: the spray-dried HepB vaccine formulations were stable for at least 24 months at 37°C while several MenA vaccine formulations exhibited complete stability at temperatures up to 60°C. This study demonstrates the feasibility of producing thermostable vaccines with advanced processing and formulation technologies. [Copyright &y& Elsevier]
Details
- Language :
- English
- ISSN :
- 0264410X
- Volume :
- 28
- Issue :
- 31
- Database :
- Academic Search Index
- Journal :
- Vaccine
- Publication Type :
- Academic Journal
- Accession number :
- 52348705
- Full Text :
- https://doi.org/10.1016/j.vaccine.2010.04.112