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Acute D2 receptor blockade induces rapid, reversible remodeling in human cortical-striatal circuits.
- Source :
-
Nature Neuroscience . Aug2010, Vol. 13 Issue 8, p920-922. 3p. 2 Graphs. - Publication Year :
- 2010
-
Abstract
- Structural remodeling has been observed in the human brain over periods of weeks to months, but the molecular mechanisms governing this process remain incompletely characterized. Using multimodal pharmaco-neuroimaging, we found that acute D2 receptor blockade induced reversible striatal volume changes and structural-functional decoupling in motor circuits within hours; these alterations predicted acute extrapyramidal motor symptoms with high precision. Our findings suggest a role for D2 receptors in short-term neural plasticity and identify a potential biomarker for neuroleptic side effects in humans. [ABSTRACT FROM AUTHOR]
- Subjects :
- *BRAIN imaging
*NEUROPLASTICITY
*MOTOR cortex
*NEURAL circuitry
*NEUROSCIENCES
Subjects
Details
- Language :
- English
- ISSN :
- 10976256
- Volume :
- 13
- Issue :
- 8
- Database :
- Academic Search Index
- Journal :
- Nature Neuroscience
- Publication Type :
- Academic Journal
- Accession number :
- 52476802
- Full Text :
- https://doi.org/10.1038/nn.2572