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Cost-effectiveness of balloon kyphoplasty in patients with symptomatic vertebral compression fractures in a UK setting.
- Source :
-
Osteoporosis International . Sep2010, Vol. 21 Issue 9, p1599-1608. 10p. 1 Diagram, 3 Charts, 6 Graphs. - Publication Year :
- 2010
-
Abstract
- Balloon kyphoplasty (BKP) is a procedure used to treat vertebral compression fractures (VCFs). We developed a cost-effectiveness model to evaluate BKP in United Kingsdom patients with hospitalised VCFs and estimated the cost-effectiveness of BKP compared to non-surgical management. The results indicate that BKP provides a cost-effective alternative for treating these patients. VCFs of osteoporotic patients are associated with chronic pain, a reduction in health-related quality of life (QoL) and high healthcare costs. BKP is a minimally invasive procedure that has resulted in pain relief, vertebral body height-restoration, decreased kyphosis and improved physical functioning in patients with symptomatic VCFs. BKP was shown to improve health-related QoL in a 12-month interim analysis of a randomised phase-III trial. The objectives of this study were to develop a Markov cost-effectiveness model to evaluate BKP in patients with painful hospitalised VCFs and to estimate the cost-effectiveness of BKP compared with non-surgical management in a UK setting. It was assumed that QoL-benefits found at 12 months linearly approached zero during another 2 years, and that patients receiving BKP warranted six fewer hospital bed days compared with patients given non-surgical management. The procedure was associated with quality-adjusted life-years (QALY)-gains of 0.17 and cost/QALY-gains at £8,800. The results were sensitive to assumptions about avoided length of hospital-stay and persistence of kyphoplasty-related QoL-benefits. In conclusion, the results indicate that BKP provides a cost-effective alternative for treating patients with hospitalised VCFs in a UK-setting. [ABSTRACT FROM AUTHOR]
- Subjects :
- *VERTEBRAE
*OSTEOPOROSIS treatment
*KYPHOSIS
*CHRONIC pain
*QUALITY of life
*MARKOV processes
*MEDICAL care costs
*DISEASES
*PATIENTS
*THERAPEUTICS
*BONE surgery
*BONE fractures
*SPINAL injury treatment
*COST effectiveness
*ENDOSCOPIC surgery
*MATHEMATICAL models
*MORTALITY
*OSTEOPOROSIS
*SPINAL surgery
*THEORY
*RELATIVE medical risk
*DISEASE complications
Subjects
Details
- Language :
- English
- ISSN :
- 0937941X
- Volume :
- 21
- Issue :
- 9
- Database :
- Academic Search Index
- Journal :
- Osteoporosis International
- Publication Type :
- Academic Journal
- Accession number :
- 52576138
- Full Text :
- https://doi.org/10.1007/s00198-009-1096-6