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Pseudo-template molecularly imprinted polymer for selective screening of trace β-lactam antibiotics in river and tap water
- Source :
-
Journal of Chromatography A . Aug2010, Vol. 1217 Issue 33, p5420-5426. 7p. - Publication Year :
- 2010
-
Abstract
- Abstract: To assess the potential risks associated with the environmental exposure of β-lactam antibiotics (BLAs), the monitoring of the occurrence, distribution, and fate of these emerging contaminants in the environment is required. Herein, we demonstrate a molecularly imprinted solid-phase extraction (MISPE) method for selective and reliable screening of trace BLAs in river and tap water. By developing a low-temperature photopolymerization, highly selective molecularly imprinted polymers (MIPs) for five BLAs (penicillin G, amoxicillin, ampicillin, nafcillin and mezlocillin) were synthesized. Nafcillin was chosen as a pseudo template to make the MIP sorbent (Nafc-MIP), which was used in pseudo-template MISPE for preconcentration of the other four BLAs from river and tap water. The application of pseudo-template MISPE overcomes the template bleeding, which significantly elevates the sample background and restricts the application of MIP for detection of the target BLA below 2μg/L. The average recoveries of BLAs are in the range of 60–90% when Nafc-MIP was adopted as the selective MISPE sorbent. The developed method was validated, and applied to the screening of trace β-lactam antibiotics in river and tap water. The linearity of the calibration curve for each BLA was observed over the range of 0.1–20μg/L (r >0.998). The β-lactam antibiotics were found within the range of 0–9.56μg/L in river water at the downstream of antibiotics manufacturers, and none were detected in the tap water. [Copyright &y& Elsevier]
Details
- Language :
- English
- ISSN :
- 00219673
- Volume :
- 1217
- Issue :
- 33
- Database :
- Academic Search Index
- Journal :
- Journal of Chromatography A
- Publication Type :
- Academic Journal
- Accession number :
- 52578604
- Full Text :
- https://doi.org/10.1016/j.chroma.2010.06.044