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Trinuclear Ru(II) polypyridyl complexes as human telomeric quadruplex DNA stabilizers
- Source :
-
Inorganic Chemistry Communications . Sep2010, Vol. 13 Issue 9, p1050-1053. 4p. - Publication Year :
- 2010
-
Abstract
- Abstract: Two new trinuclear ruthenium(II) complexes [(bpy)6Ru3(tpbip)]6+ (1) and [(bpy)6Ru3(tptaip)]6+ (2) (bpy=2,2′-bipyridine, tpbip=1,3,5-tris(1,10-phenanthroline-[5,6-d]imidazol-2-yl)-benzene, tptaip=2,4,6-tri(1,10-phenanthroline-[5,6-d]imidazol-2-yl)-1,3,5-triazine) have been synthesized and characterized. The interaction of human telomeric DNA with Ru(II) complexes was explored by means of CD spectroscopy, fluorescence titration, ITC and FRET melting. Results indicated that two complexes not only induce a remarkable conformational change of human telomeric DNA, but also have the ability to stabilize the G-quadruplex. [Copyright &y& Elsevier]
Details
- Language :
- English
- ISSN :
- 13877003
- Volume :
- 13
- Issue :
- 9
- Database :
- Academic Search Index
- Journal :
- Inorganic Chemistry Communications
- Publication Type :
- Academic Journal
- Accession number :
- 52581278
- Full Text :
- https://doi.org/10.1016/j.inoche.2010.06.008