Treg Cell Numbers and Function in Patients With Antibiotic-Refractory or Antibiotic-Responsive Lyme Arthritis.

The article presents a study which examined the function and number of Treg cells in patients with antibiotic-refractory Lyme arthritis. According to the authors, Treg cells were functional in patients with antibiotic-refractory arthritis while in some patients, higher number of Treg cells in synovial fluid appeared to be involved in the treatment of arthritis. In a mouse model, the authors explain that antibiotic-refractory arthritis and lower number of Treg cells were unable to achieve the treatment of synovial disease.