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Conjugation of some NSAIDs with 5-phenyl-2-aminothiazole for reduced ulcerogenicity.
- Source :
-
Thai Journal of Pharmaceutical Sciences . Apr-Jun2010, Vol. 34 Issue 2, p49-57. 9p. 1 Diagram, 3 Charts, 4 Graphs. - Publication Year :
- 2010
-
Abstract
- Analgesic drugs containing free acidic group were reacted with N, N' carbonyldiimidazole to prepare the acylimidazole derivatives. They were further reacted with 5-phenyl-2-amino thiazole nucleus to obtain the corresponding amides. All the compounds were found to retain analgesic-antiinflammatory activities with much lesser NSAID-induced GI complications when compared with the standard. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 01254685
- Volume :
- 34
- Issue :
- 2
- Database :
- Academic Search Index
- Journal :
- Thai Journal of Pharmaceutical Sciences
- Publication Type :
- Academic Journal
- Accession number :
- 52704991