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Toxicity of trastuzumab labeled 177Lu on MCF7 and SKBr3 cell lines
- Source :
-
Applied Radiation & Isotopes . Oct2010, Vol. 68 Issue 10, p1964-1966. 3p. - Publication Year :
- 2010
-
Abstract
- Abstract: In this study, we labeled trastuzumab with 177Lu to synthesize a new radiopharmaceutical for therapy of breast cancer and at the first stage investigated its therapeutic effects on SKBr3 and MCF7 breast cancer cell lines. Trastuzumab-177Lu showed very good in-vitro characteristics such as high radiochemical purity (91±0.9%), good stability in PBS buffer (86±2.3%) and blood serum (81±2.7%) up to 96h, appropriate immunoreactivity (85.4±1.1%) and high cytotoxicity in HER2 expression cells. 5 fold increase in toxicity of trastuzumab-177Lu was observed when compared with unlabeled trastuzumab on SKBr3 cells. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 09698043
- Volume :
- 68
- Issue :
- 10
- Database :
- Academic Search Index
- Journal :
- Applied Radiation & Isotopes
- Publication Type :
- Academic Journal
- Accession number :
- 52820213
- Full Text :
- https://doi.org/10.1016/j.apradiso.2010.05.004