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Implication of the RAGEāEN-RAGE axis in endometriosis
- Source :
-
International Journal of Gynecology & Obstetrics . Sep2010, Vol. 110 Issue 3, p199-202. 4p. - Publication Year :
- 2010
-
Abstract
- <bold>Objective: </bold>To investigate the involvement of the receptor gene for advanced glycation (RAGE), its ligand EN-RAGE, and COX-2 in endometriosis.<bold>Methods: </bold>The mRNA and protein expression of the corresponding genes were determined from endometriotic cells from 28 study patients and healthy endometrial stromal cells from 20 controls by semiquantitative RT-PCR and Western blot analysis, respectively, using beta-actin as an invariant control.<bold>Results: </bold>The expression of COX-2, RAGE, and EN-RAGE was significantly increased, as evidenced by the significantly greater mRNA and protein expression in the cells of the study patients (P<0.001). Previous treatment for endometriosis did not lessen mRNA and protein expression (P<0.001).<bold>Conclusion: </bold>Our findings strengthen the hypothesis of an underlying inflammation in the pathophysiology of endometriosis and suggest exploring anti-inflammatory therapies as adjunct treatment. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 00207292
- Volume :
- 110
- Issue :
- 3
- Database :
- Academic Search Index
- Journal :
- International Journal of Gynecology & Obstetrics
- Publication Type :
- Academic Journal
- Accession number :
- 52822176
- Full Text :
- https://doi.org/10.1016/j.ijgo.2010.03.037