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Egress of HSV-1 capsid requires the interaction ofVP26 and a cellular tetraspanin membrane protein.
- Source :
-
Virology Journal . 2010, Vol. 7, p156-167. 12p. - Publication Year :
- 2010
-
Abstract
- HSV-1 viral capsid maturation and egress from the nucleus constitutes a self-controlled process of interactions between host cytoplasmic membrane proteins and viral capsid proteins. In this study, a member of the tetraspanin superfamily, CTMP-7, was shown to physically interact with HSV-1 protein VP26, and the VP26-CTMP-7 complex was detected both in vivo and in vitro. The interaction of VP26 with CTMP-7 plays an essential role in normal HSV-1 replication. Additionally, analysis of a recombinant virus HSV-1-UG showed that mutating VP26 resulted in a decreased viral replication rate and in aggregation of viral mutant capsids in the nucleus. Together, our data support the notion that biological events mediated by a VP26 - CTMP-7 interaction aid in viral capsid enveloping and egress from the cell during the HSV-1 infectious process. [ABSTRACT FROM AUTHOR]
- Subjects :
- *VIRAL replication
*PROTEINS
*VIRUS diseases
*T cells
*REPRODUCTION
Subjects
Details
- Language :
- English
- ISSN :
- 1743422X
- Volume :
- 7
- Database :
- Academic Search Index
- Journal :
- Virology Journal
- Publication Type :
- Academic Journal
- Accession number :
- 52859252
- Full Text :
- https://doi.org/10.1186/1743-422X-7-156