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Evidences of protection against blood-stage infection of Plasmodium falciparum by the novel protein vaccine SE36
- Source :
-
Parasitology International . Sep2010, Vol. 59 Issue 3, p380-386. 7p. - Publication Year :
- 2010
-
Abstract
- Abstract: An effective malaria vaccine is a public health priority. Proteins expressed during the blood-stage of the parasite life cycle have been proposed as good vaccine candidates. No such blood-stage vaccine, however, is available against Plasmodium falciparum, the deadliest Plasmodium species. We show here that P. falciparum serine repeat antigen 5 (SERA5) is a potential vaccine immunogen. We have constructed a new recombinant molecule of SERA5, namely SE36, based on previously reported SE47′ molecule by removing the serine repeats. Epidemiological study in the holo-endemic population of Solomon Islands shows highly significant correlation of sero-conversion and malaria protective immunity against this antigen. Animal experiments using non-human primates, and a human phase 1a clinical trial assessed SE36 vaccine immunogenicity. Vaccination of squirrel monkeys with SE36 protein and aluminum hydroxyl gel (SE36/AHG) conferred protection against high parasitemia and boosted serum anti-SE36 IgG after P. falciparum parasite challenge. SE36/AHG was highly immunogenic in chimpanzees, where serum anti-SE36 IgG titers last more than one year. Phase 1a clinical trial (current controlled trials, ISRCTN78679862) demonstrated the safety and immunogenicity of SE36/AHG with 30 healthy adults and 10 placebo controls. Three subcutaneous administrations of 50 and 100μg dose of SE36/AHG were well-tolerated, with no severe adverse events; and resulted in 100% sero-conversion in both dose arms. The current research results for SE36/AHG provide initial clinical validation for future trials and suggest clues/strategies for further vaccine development. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 13835769
- Volume :
- 59
- Issue :
- 3
- Database :
- Academic Search Index
- Journal :
- Parasitology International
- Publication Type :
- Academic Journal
- Accession number :
- 52878435
- Full Text :
- https://doi.org/10.1016/j.parint.2010.05.002