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Additive effect of oxitropium bromide in combination with inhaled corticosteroids in the treatment of elderly patients with chronic asthma.
- Source :
-
Allergology International . Mar1999, Vol. 48 Issue 1, p85-88. 4p. - Publication Year :
- 1999
-
Abstract
- The efficacy of the addition of inhaled oxitropium bromide in combination with inhaled corticosteroids in the treatment of elderly asthmatic patients whose asthma is not well controlled was evaluated. A randomized, open-label cross-over trial comparing 4-week treatment periods with and without regular inhalation of 200 μg of oxitropium bromide four times per day was performed. Twenty-four patients (mean age ± SD: 62 ± 7 years) completed the study. The dose of beclomethasone dipropionate in this patient group was 1300 ± 800 μg/day. Forced expiratory volume in 1 second (FEV1) was significantly improved after treatment with regular inhalation of oxitropium bromide when compared with FEV1 after treatment without oxitropium (1.73 ± 0.60 vs 1.63 ± 0.68). Both morning and evening peak expiratory flow rates were significantly greater during the treatment period with regular inhalation of oxitropium bromide. The score for dyspnea/chest tightness was also significantly improved during the oxitropium bromide period. There was no statistically significant improvement in forced vital capacity, scores for other symptoms or the frequency of rescue inhalation of fenoterol. The results of this study demonstrated that the addition of regular inhalation of oxitropium bromide is beneficial in elderly asthmatics whose asthma is not well controlled, even when treated with high-dose inhaled steroids. [ABSTRACT FROM AUTHOR]
- Subjects :
- *CORTICOSTEROIDS
*HORMONE therapy
*ASTHMA treatment
Subjects
Details
- Language :
- English
- ISSN :
- 13238930
- Volume :
- 48
- Issue :
- 1
- Database :
- Academic Search Index
- Journal :
- Allergology International
- Publication Type :
- Academic Journal
- Accession number :
- 5300291
- Full Text :
- https://doi.org/10.1046/j.1440-1592.1999.00120.x