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RNA-based antiviral immunity.
- Source :
-
Nature Reviews Immunology . Sep2010, Vol. 10 Issue 9, p632-644. 13p. 5 Diagrams, 1 Chart. - Publication Year :
- 2010
-
Abstract
- In eukaryotic RNA-based antiviral immunity, viral double-stranded RNA is recognized as a pathogen-associated molecular pattern and processed into small interfering RNAs (siRNAs) by the host ribonuclease Dicer. After amplification by host RNA-dependent RNA polymerases in some cases, these virus-derived siRNAs guide specific antiviral immunity through RNA interference and related RNA silencing effector mechanisms. Here, I review recent studies on the features of viral siRNAs and other virus-derived small RNAs from virus-infected fungi, plants, insects, nematodes and vertebrates and discuss the innate and adaptive properties of RNA-based antiviral immunity. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 14741733
- Volume :
- 10
- Issue :
- 9
- Database :
- Academic Search Index
- Journal :
- Nature Reviews Immunology
- Publication Type :
- Academic Journal
- Accession number :
- 53166482
- Full Text :
- https://doi.org/10.1038/nri2824