Synthesis of an 8-pentafluorosulfanyl analog of the antimalarial agent mefloquine

Authors :: Mo, Tingting
Mi, Xueling
Milner, Erin E.
Dow, Geoffrey S.
Wipf, Peter
Source :: Tetrahedron Letters: International Organ for the Rapid Publication of Preliminary Communications in Organic Chemistry. Sep2010, Vol. 51 Issue 39, p5137-5140. 4p.
Publication Year :: 2010
Abstract: Abstract: The 8-SF5 analog of mefloquine was synthesized in nine steps from commercially available starting materials and in five steps from a novel ortho-SF5–substituted aniline intermediate. [ABSTRACT FROM AUTHOR]

Subjects :: *MEFLOQUINE
*ANTIMALARIALS
*ANILINE
*INTERMEDIATES (Chemistry)
*FUNCTIONAL groups
*SUBSTITUTION reactions
*ORGANIC synthesis

Language :: English
ISSN :: 00404039
Volume :: 51
Issue :: 39
Database :: Academic Search Index
Journal :: Tetrahedron Letters: International Organ for the Rapid Publication of Preliminary Communications in Organic Chemistry
Publication Type :: Academic Journal
Accession number :: 53303004
Full Text :: https://doi.org/10.1016/j.tetlet.2010.07.113

Full Text Access

Tools