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MALADIA VON WILLEBRAND.
- Source :
-
Romanian Journal of Pediatrics / Revista Romana de Pediatrie . 2009, Vol. 58 Issue 4, p349-352. 4p. 1 Chart. - Publication Year :
- 2009
-
Abstract
- Described by Erik Adolf von Willebrand in 1926, it is a constitutional hemorrhagic disease, inherited in the autosomal mode. Considered initially as a thrombopathic disease, then as a prologation of the bleeding time associated to a deficit in the factor VIII, today it is defined as an absence, diminuation or a modification of the von Willebrand factor, a glycoprotein sintetized by the endotheklial cell and the megariocyte. The incidence of the disease is around 2%, being the first constitutionally hemorrhagic deficit, in front of the hemophilias. In this article we present: phisiopathologic mechanisms of the disease, clinical signs, biologic diagnosis, classification of von Willebrand disease, the differential diagnosis and treatment. [ABSTRACT FROM AUTHOR]
Details
- Language :
- Romanian
- ISSN :
- 14540398
- Volume :
- 58
- Issue :
- 4
- Database :
- Academic Search Index
- Journal :
- Romanian Journal of Pediatrics / Revista Romana de Pediatrie
- Publication Type :
- Academic Journal
- Accession number :
- 53445738