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A Deep Breath Bronchoconstricts Obese Asthmatics.
- Source :
-
Journal of Asthma . Feb2010, Vol. 47 Issue 1, p55-60. 6p. 2 Charts, 3 Graphs. - Publication Year :
- 2010
-
Abstract
- Background: Asthma is characterized by the loss of a deep breath (DB)-induced bronchodilation and bronchoprotection. Obesity causes lung restriction and increases airway resistance, which may further worsen the capacity of a DB to induce bronchodilation; however, whether increasing BMI impairs the bronchodilatory response to a DB in asthmatics is unknown. Methods: The population consisted of 99 subjects, 87 with moderate to severe persistent asthma and 12 obese control subjects. Using transfer impedance we derived airway resistance (Raw). Participants breathed for 1 minute and took a slow DB followed by passive exhalation to functional residual capacity (FRC) and tidal breathing for another minute. Results: After a DB, obese asthmatics had the largest percent increase in Raw (median 9.8% interquartile range [IQR] 3.1–15.1), compared with overweight (6.5% IQR −1.3, 12.1) and lean (0.7% IQR −3, 7.9) asthmatics and obese controls (2.5% IQR –.6, 11) (p for trend = 0.008). The association between the percent increase in Raw after a DB and BMI as a continuous variable was significant ( p = 0.02). Conclusions: In obese, moderate to severe and poorly controlled asthmatics, a DB results in increased Raw. This phenomenon was not observed in leaner asthmatics of similar severity or in obese control subjects. [ABSTRACT FROM AUTHOR]
- Subjects :
- *ASTHMATICS
*ASTHMA
*OBSTRUCTIVE lung diseases
*METABOLIC disorders
*BODY weight
Subjects
Details
- Language :
- English
- ISSN :
- 02770903
- Volume :
- 47
- Issue :
- 1
- Database :
- Academic Search Index
- Journal :
- Journal of Asthma
- Publication Type :
- Academic Journal
- Accession number :
- 53469456
- Full Text :
- https://doi.org/10.3109/02770900903318330